Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury
Abstract Background Proline-rich tyrosine kinase 2 (Pyk2) is essential in neutrophil degranulation and chemotaxis in vitro.However, its effect on the process of lung inflammation and edema formation during LPS induced acute lung injury (ALI) remains unknown.The goal of the present study was to determine the effect of inhibiting Pyk2 on LPS-induced